Translation and analysis of words by ChatGPT artificial intelligence
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IGH - translation to English
![Schematic diagram of a typical antibody showing two Ig heavy chains (purple) joined by [[disulfide bond]]s to two Ig light chains (green). The constant (C) and variable (V) domains are shown.](https://commons.wikimedia.org/wiki/Special:FilePath/AntibodyChains.svg?width=200 "Schematic diagram of a typical antibody showing two Ig heavy chains (purple) joined by [[disulfide bond]]s to two Ig light chains (green). The constant (C) and variable (V) domains are shown.")
Wikipedia
The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin). In human genome, the IgH gene loci are on chromosome 14.
A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Several different types of heavy chain exist that define the class or isotype of an antibody. These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2, etc.). Production of a viable heavy chain is a key step in B cell maturation. If the heavy chain is able to bind to a surrogate light chain and move to the plasma membrane, then the developing B cell can begin producing its light chain.
The heavy chain doesn't always have to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain in the absence of light chain, which then can allow the heavy chain to bind to a heavy-chain binding protein.
